Busulfan series


Busulfan is a bi-functional alkylating agent that interferes with DNA replication and RNA transcription, is administered at both low (1-2 mg/kg) and high doses (16mg/kg) in combined chemotherapy prior to bone marrow transplant. Pharmacokinetic data is often investigated as the bioavailability of the drug is highly variable and there is a narrow therapeutic range.

Also known as


Request a test

To request this test please send sample with a request providing patient ID (three identifiers), specimen information, assay required, relevant clinical details and sender information. Before sending sample please read details on requesting and labelling by clicking on the link. Please also refer to any additional information provided for this test.

Additional information

Must arrive in lab within 30mins of collection and be frozen at �20�C. Sampling times are essential. If sending from an external lab please contact the Metabolic Lab.

Sending address

Chemical Pathology Reception
Level 1, Camelia Botnar Building
Great Ormond Street Hospital
Great Ormond Street

Laboratory service

Chemical Pathology

Sample requirements

1ml minimum of EDTA plasma only.

Reference range

Not applicable

Turnaround time

Same day service

Disease / group

Busulfan is administered in chemotherapy prior to bone marrow transplant


Upon request

Call in advance?

Must be pre-booked with the laboratory at least a week in advance. Metabolic Lab ext 5225 or Email Busulphan_booking@gosh.nhs.uk

Chemical Pathology

The Chemical Pathology Laboratory provides an extensive range of services covering both routine biochemistry and specialised analysis and interpretation.

© 2011 Great Ormond Street Hospital for Children NHS Trust