Heart and lung transplant serology assessment


Any patient undergoing a heart or a heart and lung transplant is subject to a pre-transplant serology screen, as is their donor. A combination of automated detection by enzyme linked fluorescent assays (ELFA) and manual enzyme linked immunoassays (EIA) is used for the detection of Toxoplasma gondii total antibody, as well as VZV, measles, CMV, rubella, HSV and EBV VCA IgG. The immune status of the patient to each organism is therefore determined; the potential for primary infection, re-infection or reactivation when immunosuppressed is thus known and, where possible, recipients and donors are matched according to their CMV and EBV serostatus. The pre-transplant assessment also includes blood borne virus screening by ELFA or EIA for anti-HIV antibodies and p24 antigen, Hepatitis B surface antigen and Hepatitis C antibody and core antigen. Post transplant patients are reviewed annually using a subset of this screen, to determine seroconversion following CMV and EBV infection, by the detection of IgG.

Also known as

Transplant assessment, transplant serology

Request a test

To request this test please send sample with a request providing patient ID (three identifiers), specimen information, assay required, relevant clinical details and sender information. Before sending sample please read details on requesting and labelling by clicking on the link. Please also refer to any additional information provided for this test.

Additional information

Individual tests from the screen can also be requested, as appropriate

Sending address

Microbiology, Virology and Infection Control Level 4, Camelia Botnar Laboratories Great Ormond Street Hospital for Children Great Ormond Street London WC1N 3JH DX number: DX6640203 DX Exchange: Bloomsbury 91WC

Laboratory service

Microbiology, Virology and Infection Control

Sample requirements

Serum (10ml in clotted blood tube)

Reference range

Not applicable

Turnaround time

Automated results within 24 hours, manual results within 7 days

Disease / group

Viral infection, viral immunity


Upon request

Call in advance?

Not required

Microbiology, Virology and Infection Control

Our laboratory performs a wide range of routine and specialist investigations in Bacteriology, Virology and PCR.

© 2011 Great Ormond Street Hospital for Children NHS Trust