Description
A locus specific dual-colour breakapart probe set for the detection of EVI1 rearrangements, but will not identify the partner gene involved. This probe set may also be used in other disease types/referral reasons for eluciation of rearrangements or locus enumeration.
Request a test
When requesting this test please use the referral form provided. Please also refer to any additional information provided for this test.
Additional information
FISH (fluorescence in-situ hybridisation) is a technique which used as both a stand-alone test and as an adjuct to G-band analysis. It uses uses fluorescently-labelled complementary sequesnces of DNA applied to material fixed on slides, this allows visulisation of specific sequences in both metaphase and interphase cells. Probes are designed for the analysis of specific rearrangments, or may be used for the enumeration of loci present in a cell. The information gained from FISH analyses may be useful for both diagnostic and prognostic purposes. May be performed as a reflex test on existing karyotyping cases.
Sending address
Paediatric Malignancy Unit
Great Ormond Street Hospital for Sick Children
Level 2, Camelia Botnar Laboratories
Great Ormond Street
London
WC1N 3JH
Laboratory service
Specialist Integrated Haematology and Malignancy Diagnostic Service- Acquired Genomics
Sample requirements
Please refer to FISH (Tissue Fresh/frozen), FISH (FFPE) or FISH (Bone marrow/peripheral blood) as appropriate.
Reference range
Not applicable
Turnaround time
Urgent: 3 days (FISH only) As part of full karyotype anaysis; see 'Karyotype' turnaround times.
Disease / group
AML, MDS, acute meyeloid leukaemia, myelodysplastic syndrome
Cost
Upon request
Call in advance?
Please call in advance to discuss requirements