The Haematology department provides support to Great Ormond Street Hospital (GOSH) and UCL Institute of Child Health (ICH) research projects and clinical trials.


The specialist Molecular Haematology section is currently investigating T and B cell immune reconstitution following haematopoietic stem cell transplantation (HSCT), thymus transplant or gene therapy. This is carried out using Next Generation Sequencing (NGS) T and B cell repertoire diversity in collaboration with research groups at UCL. By combining this with the TRECs and KRECs assay we are able to provide novel information for immune reconstitution following routine or novel therapies. The lab is actively involved in using dried blood spots (Guthrie cards) in conjunction with an adapted TRECs test to screen newborns for Severe Combined Immunodeficiency (SCID). In addition the lab has developed an assay to measure the levels of a commonly used antibody (Campath or Alemtuzumab) in patient serum and has collaborated with a team in Leiden and Utrecht to understand how this drug can affect outcome after HSCT.


Selected Recent Publications


EG Davies, M Cheung, K Gilmour, J Marmaris , J Curry, A Furmanski, N Sebire, S Adams et al.(2017). Thymus Transplantation for Complete DiGeorge Syndrome: European Experience. Journal of Allergy and Clinical Immunology.


W Qasim, H Zhan, S Samarasinghe, S Adams, P Amrolia, S Stafford, K Butler, C Rivat et al. (2017). Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells. Sci Transl Med. 2017 Jan 25;9(374). pii: eaaj2013. doi: 10.1126/scitranslmed.aaj2013


C Bacchelli, Moretti, S Adams,   M Carmo, HC Stanescu, K Pearce, M Madkaikar, KC Gilmour et al. (2016). Mutations in LAT lead to a novel form of severe combined immunodeficiency. Journal of Allergy and Clinical Immunology 139(2):634-642.


K Rao, S Adams, W Qasim, R Chiesa, A Worth, J Silva, G Lucchini, P Veys, P Amrolia (2016). Impact of stem cell source on long term chimerism and event free survival in children with primary immunodeficiency disorders. Journal of Allergy and Clinical Immunology 138(4):1152-1160.


SP Adams, M Wilson, E Harb, L Fairbanks, J Xu-Bayford, L Brown, L Kearney, M Madkaikar, HB Gaspar (2015). Spectrum of mutations in a cohort of UK patients with ADA deficient SCID: segregation of genotypes with specific ethnicities. Clinical Immunology 161:174-179.


O Nikolajeva, A Worth, R Hague, N Martinez-Alier, S Choo, S Adams, EG Davies, HB Gaspar (2015). Adenosine Deaminase Deficient Severe Combined Immunodeficiency Presenting as Atypical Haemolytic Uraemic Syndrome. Journal of Clinical Immunology 35(4):366-72.


© 2011 Great Ormond Street Hospital for Children NHS Trust