Haematology
The Haematology department provides support to Great Ormond
Street Hospital (GOSH) and UCL Institute of Child Health (ICH)
research projects and clinical trials.
The specialist Molecular Haematology section is currently
investigating T and B cell immune reconstitution following
haematopoietic stem cell transplantation (HSCT), thymus transplant
or gene therapy. This is carried out using Next Generation
Sequencing (NGS) T and B cell repertoire diversity in collaboration
with research groups at UCL. By combining this with the TRECs and
KRECs assay we are able to provide novel information for immune
reconstitution following routine or novel therapies. The lab is
actively involved in using dried blood spots (Guthrie cards) in
conjunction with an adapted TRECs test to screen newborns for
Severe Combined Immunodeficiency (SCID). In addition the lab has
developed an assay to measure the levels of a commonly used
antibody (Campath or Alemtuzumab) in patient serum and has
collaborated with a team in Leiden and Utrecht to understand how
this drug can affect outcome after HSCT.
Selected Recent Publications
EG Davies, M Cheung, K Gilmour, J Marmaris , J Curry, A
Furmanski, N Sebire, S Adams et al.(2017). Thymus
Transplantation for Complete DiGeorge Syndrome: European
Experience. Journal of Allergy and Clinical
Immunology.
W Qasim, H Zhan, S Samarasinghe, S Adams, P Amrolia, S Stafford,
K Butler, C Rivat et al. (2017). Molecular remission of
infant B-ALL after infusion of universal TALEN gene-edited CAR T
cells. Sci Transl Med. 2017 Jan 25;9(374). pii: eaaj2013.
doi: 10.1126/scitranslmed.aaj2013
C Bacchelli, Moretti, S Adams, M Carmo, HC
Stanescu, K Pearce, M Madkaikar, KC Gilmour et al. (2016).
Mutations in LAT lead to a novel form of severe combined
immunodeficiency. Journal of Allergy and Clinical
Immunology 139(2):634-642.
K Rao, S Adams, W Qasim, R Chiesa, A Worth, J Silva, G Lucchini,
P Veys, P Amrolia (2016). Impact of stem cell source on
long term chimerism and event free survival in children with
primary immunodeficiency disorders. Journal of Allergy and
Clinical Immunology 138(4):1152-1160.
SP Adams, M Wilson, E Harb, L Fairbanks, J Xu-Bayford, L Brown,
L Kearney, M Madkaikar, HB Gaspar (2015). Spectrum of
mutations in a cohort of UK patients with ADA deficient SCID:
segregation of genotypes with specific ethnicities.
Clinical Immunology 161:174-179.
O Nikolajeva, A Worth, R Hague, N Martinez-Alier, S Choo, S
Adams, EG Davies, HB Gaspar (2015). Adenosine Deaminase
Deficient Severe Combined Immunodeficiency Presenting as Atypical
Haemolytic Uraemic Syndrome. Journal of Clinical
Immunology 35(4):366-72.